The 50th Anniversary Kit and Breech Lock Challenger Kit will work for both rifle and pistol cartridges. What differentiates these kits is the way you prime. The Anniversary Kit is geared for those who prefer to prime on the press (typically customers reloading handgun cartridges since there is minimal case conditioning required). The Breech Lock Challenger Press Kit is for those who prefer to prime off the press using the New Auto-Prime (typically customers reloading rifle cartridges since cases need to be trimmed).
Both kits are designed to be "Generic", to which one adds the appropriate die set(s) for the cartridge(s) you wish to reload. Only Lee Dies include the shell holders (except RGB) that is necessary to use your dies on the press. It accommodates both the beginner and the experienced.
For rifle calibers, one should also add the appropriate Case Length Gauge & Shell Holder or Quick Trim Die to go with the case trimming tools included in the kit. Pistol cases seldom need to be trimmed as they generally wear out before actually needing it. We do make them however for those people who want the peace of mind. Case Length Gauge & Shell Holders and Quick Trim Dies can be found on the "Case Conditioning Tools" page in our catalog and website: http://leeprecision.com/Case-Length-Gauge-Holder/